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Welchrom® WCX is a weak cation exchange extraction column based on silica gel. The functional group bonded on the silica gel surface is carboxyl group with pKa of 3.8. Since the carboxylic group is bonded, the anion exchange effect is not too strong, so there is no need to elute the target compound with strong basic elution solvent. Welchrom® WCX is more suitable for the adsorption and retention of strong cations because such strong cationic targets interact strongly with SCX packing materials and are difficult to be eluted from SCX packing materials.
