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Agilent ZORBAX Rx columns are made from pure porous silica microspheres and are optimized for high throughput analysis. Rx-C18 is recommended for alternate selectivity at low pH relative to Eclipse XDB-C18 and StableBond SB-C18. With low acidity and metal content, Rx-SIL is ideal for normal-phase separation of polar compounds that exhibit poor peak symmetry on more acidic silica. The Rx-SIL is also stronger than other silica types and is less acidic than the ZORBAX-SIL.