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The StableBond packing is made by chemically bonding a sterically-protected C8 stationary phase to a specially prepared, high-purity ZORBAX porous silica microsphere. The special ZORBAX Silica support is designed to reduce or eliminate strong adsorption of basic compounds. The densely covered, sterically protected, diisopropyl n-octylsilane stationary phase is chemically stable and gives longer column life. As a result, Agilent ZORBAX SB-C8 is a stable, reversed-phase packing that can be used for basic, neutral, or acidic samples. It is particularly well-suited for use with aggressive mobile phases (for example, pH<2, high ionic strength, ion-pair additives, etc.) since the steric protection of the bonded phase resists degradation caused by such mobile phases. This material has also been shown to be stable when operated at temperatures up to 80°C. These characteristics are particularly important for use in methods that need long-term stability and reproducibility. |